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Achieving the Sustainable Development Goals in health and well-being requires scaling up successfully tested interventions that catalyze communities to reflect on and challenge existing social norms that lead to poor sexual and reproductive health among adolescents and youth. Unfortunately many pilot projects are conducted but few are scaled up. The USAID-funded Gender Roles, Equality and Transformations (GREAT) Project was a six-and-a-half year implementation research and delivery science initiative to develop, test, and scale up an intervention aimed at promoting gender equality, reducing gender-based violence, and improving sexual and reproductive health among adolescents in northern Uganda. A review of the lessons learned from the GREAT project offers insights into the art and science of implementing, documenting, and evaluating scale-up.